3G70
Design and Preparation of Potent, Non-Peptidic, Bioavailable Renin Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Renin | polymer | 341 | 37405.2 | 2 | UniProt (P00797) Pfam (PF00026) | Homo sapiens (human) | Angiotensinogenase |
| 2 | C, F (A, B) | (1R,5S)-7-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide | non-polymer | 647.0 | 2 | Chemie (A5T) | |||
| 3 | D, G (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | E, H (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 374 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 340 (UniProt: P00797)
| PDB | External Database | Details |
|---|---|---|
| His 341 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74810.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1892.6 | |
| All* | Total formula weight | 76702.9 |
