3G6G
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32726.6 | 2 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (chicken) | pp60c-src, p60-Src, c-Src |
| 2 | C, E (A, B) | N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide | non-polymer | 615.7 | 2 | Chemie (G6G) PubChem (25195368) | |||
| 3 | D, F (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | expression tag |
| His 249 | - | expression tag |
| Met 250 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65453.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1415.6 | |
| All* | Total formula weight | 66868.9 |
