3G6G
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32726.6 | 2 | UniProt (P00523) Pfam (PF07714) In PDB | Gallus gallus (chicken) | pp60c-src, p60-Src, c-Src |
2 | A, B | N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide | non-polymer | 615.7 | 2 | Chemie (G6G) | |||
3 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
PDB | External Database | Details |
---|---|---|
Gly 248 | - | expression tag |
His 249 | - | expression tag |
Met 250 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 65453.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1415.6 | |
All* | Total formula weight | 66868.9 |