3G58
Crystal structure of human phosphodiesterase 4d with d155988/pmnpq
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 381 | 43790.2 | 4 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (human) | DPDE3, PDE43 |
| 2 | AA, E, M, T (D, A, B, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | BA, F, N, U (D, A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | CA, H, O, V (D, A, B, C) | 8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline | non-polymer | 341.4 | 4 | Chemie (988) | |||
| 6 | DA, EA, FA, GA, HA... (D, A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 7 | IA, JA, KA, LA (A, B, C, D) | water | water | 18.0 | 1144 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 244 - 617 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Met 243 | - | expression tag |
| Ala 579 | Ser 715 | engineered mutation |
| Ala 581 | Ser 717 | engineered mutation |
| His 618 | - | expression tag |
| His 619 | - | expression tag |
| His 620 | - | expression tag |
| His 621 | - | expression tag |
| His 622 | - | expression tag |
| His 623 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 175160.7 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 2875.5 | |
| All* | Total formula weight | 178036.2 |
