3G49
N-(Pyridin-2-yl) Arylsulfonamide Inhibitors of 11b-Hydroxysteroid Dehydrogenase Type 1: Discovery of PF-915275
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 11-beta-hydroxysteroid dehydrogenase 1 | polymer | 277 | 30450.3 | 4 | UniProt (Q6QLL4) Pfam (PF00106) | Cavia porcellus (guinea pig) | Corticosteroid 11-beta-dehydrogenase isozyme 1, 11-beta-HSD1, 11-DH |
| 2 | E, G, H, I (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 3 | F, J (A, D) | 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide | non-polymer | 395.9 | 2 | Chemie (3G4) | |||
| 4 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 121801.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3765.4 | |
| All* | Total formula weight | 125566.7 |
