3FZK
Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heat shock cognate 71 kDa protein | polymer | 381 | 42086.5 | 1 | UniProt (P11142) Pfam (PF00012) | Homo sapiens (Human) | Heat shock 70 kDa protein 8 |
| 2 | B (B) | BAG family molecular chaperone regulator 1 | polymer | 114 | 13157.2 | 1 | UniProt (Q99933) Pfam (PF02179) | Homo sapiens (Human) | BAG-1, Bcl-2-associated athanogene 1, Glucocorticoid receptor-associated protein RAP46 |
| 3 | C (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E (A) | (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | non-polymer | 441.3 | 1 | Chemie (3BK) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 277 | Chemie (HOH) |
Sequence modifications
A: 4 - 381 (UniProt: P11142)
B: 151 - 263 (UniProt: Q99933)
| PDB | External Database | Details |
|---|---|---|
| Tyr 1 | - | expression tag |
| Phe 2 | - | expression tag |
| Gln 3 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 150 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55243.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 598.9 | |
| All* | Total formula weight | 55842.6 |
