3FZH

Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Heat shock cognate 71 kDa protein	polymer	381	42086.5	1	UniProt (P11142) Pfam (PF00012) In PDB	Homo sapiens (Human)	Heat shock 70 kDa protein 8
2	B	BAG family molecular chaperone regulator 1	polymer	114	13157.2	1	UniProt (Q99933) Pfam (PF02179) In PDB	Homo sapiens (Human)	BAG-1, Bcl-2-associated athanogene 1, Glucocorticoid receptor-associated protein RAP46
3	A	(2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol	non-polymer		282.3	1	Chemie (3BH)
4		water	water		18.0	309	Chemie (HOH)

Sequence modifications

A: 4 - 381 (UniProt: P11142)

PDB	External Database	Details
Tyr 1	-	expression tag
Phe 2	-	expression tag
Gln 3	-	expression tag

B: 151 - 263 (UniProt: Q99933)

PDB	External Database	Details
Gly 150	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	55243.7
Non-Polymers*	Number of molecules	1
	Total formula weight	282.3
All*	Total formula weight	55526.0

*Water molecules are not included.