3FWV

Crystal Structure of a Redesigned TPR Protein, T-MOD(VMY), in Complex with MEEVF Peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Hsc70/Hsp90-organizing protein	polymer	128	15204.3	2	UniProt (P31948) Pfam (PF13181) Pfam (PF00515) In PDB	Homo sapiens (human)	Hop, Stress-induced-phosphoprotein 1, STI1, Transformation-sensitive protein IEF SSP 3521, NY-REN-11 antigen
2	C, D	Heat shock protein HSP 90-beta	polymer	6	679.8	2	UniProt (P08238) In PDB	synthetic construct	HSP 90, HSP 84
3	A, B	NICKEL (II) ION	non-polymer		58.7	4	Chemie (NI)
4		water	water		18.0	85	Chemie (HOH)

Sequence modifications

A, B: 223 - 349 (UniProt: P31948)

PDB	External Database	Details
Ser 222	-	expression tag
Val 263	Thr 263	engineered mutation
Met 298	Gln 298	engineered mutation
Tyr 301	Lys 301	engineered mutation
Lys 334	Asp 334	engineered mutation

C, D: 1 - 5 (UniProt: P08238)

PDB	External Database	Details
Ace 0	-	acetylation
Phe 5	Asp 723	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	31768.2
Non-Polymers*	Number of molecules	4
	Total formula weight	234.8
All*	Total formula weight	32003.0

*Water molecules are not included.