3FWV
Crystal Structure of a Redesigned TPR Protein, T-MOD(VMY), in Complex with MEEVF Peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hsc70/Hsp90-organizing protein | polymer | 128 | 15204.3 | 2 | UniProt (P31948) Pfam (PF13181) Pfam (PF00515) | Homo sapiens (human) | Hop, Stress-induced-phosphoprotein 1, STI1, Transformation-sensitive protein IEF SSP 3521, NY-REN-11 antigen |
| 2 | C, D (C, D) | Heat shock protein HSP 90-beta | polymer | 6 | 679.8 | 2 | UniProt (P08238) | synthetic construct | HSP 90, HSP 84 |
| 3 | E, F, G, H (A, B) | NICKEL (II) ION | non-polymer | 58.7 | 4 | Chemie (NI) | |||
| 4 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A, B: 223 - 349 (UniProt: P31948)
C, D: 1 - 5 (UniProt: P08238)
| PDB | External Database | Details |
|---|---|---|
| Ser 222 | - | expression tag |
| Val 263 | Thr 263 | engineered mutation |
| Met 298 | Gln 298 | engineered mutation |
| Tyr 301 | Lys 301 | engineered mutation |
| Lys 334 | Asp 334 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ace 0 | - | acetylation |
| Phe 5 | Asp 723 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 31768.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 234.8 | |
| All* | Total formula weight | 32003.0 |
