3FPD

G9a-like protein lysine methyltransferase inhibition by BIX-01294

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5	polymer	261	30232.4	2	UniProt (Q9H9B1) Pfam (PF05033) Pfam (PF00856)	Homo sapiens (human)	Histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, Euchromatic histone-lysine N-methyltransferase 1, Eu-HMTase1, G9a-like protein 1, GLP1, Lysine N-methyltransferase 1D
2	C, I (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
3	D, J (A, B)	N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine	non-polymer		490.6	2	Chemie (Q4A)
4	E, F, G, H, K... (A, B)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
5	O, P (A, B)	water	water		18.0	119	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	60464.7
Non-Polymers*	Number of molecules	12
	Total formula weight	2273.4
All*	Total formula weight	62738.1

*Water molecules are not included.