3FNM

Crystal structure of acivicin-inhibited gamma-glutamyltranspeptidase reveals critical roles for its C-terminus in autoprocessing and catalysis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Gamma-glutamyltranspeptidase (Ggt) Large subunit	polymer	377	40577.4	2	UniProt (O25743) Pfam (PF01019) In PDB	Helicobacter pylori (Campylobacter pylori)
2	B, D	Gamma-glutamyltranspeptidase (Ggt) Small subunit	polymer	188	20410.2	2	UniProt (O25743) Pfam (PF01019) In PDB	Helicobacter pylori (Campylobacter pylori)
3	B, D	(2S)-AMINO[(5S)-3-CHLORO-4,5-DIHYDROISOXAZOL-5-YL]ACETIC ACID	non-polymer		178.6	2	Chemie (AVN)
4		water	water		18.0	534	Chemie (HOH)

Sequence modifications

A, C: 25 - 379 (UniProt: O25743)

PDB	External Database	Details
Met 3	-	EXPRESSION TAG
Gly 4	-	EXPRESSION TAG
Ser 5	-	EXPRESSION TAG
Ser 6	-	EXPRESSION TAG
His 7	-	EXPRESSION TAG
His 8	-	EXPRESSION TAG
His 9	-	EXPRESSION TAG
His 10	-	EXPRESSION TAG
His 11	-	EXPRESSION TAG
His 12	-	EXPRESSION TAG
Ser 13	-	EXPRESSION TAG
Ser 14	-	EXPRESSION TAG
Gly 15	-	EXPRESSION TAG
Leu 16	-	EXPRESSION TAG
Val 17	-	EXPRESSION TAG
Pro 18	-	EXPRESSION TAG
Arg 19	-	EXPRESSION TAG
Gly 20	-	EXPRESSION TAG
Ser 21	-	EXPRESSION TAG
His 22	-	EXPRESSION TAG
Met 23	-	EXPRESSION TAG
Ala 24	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	121975.1
Non-Polymers*	Number of molecules	2
	Total formula weight	357.1
All*	Total formula weight	122332.3

*Water molecules are not included.