3FKO

P38 kinase crystal structure in complex with RO3668

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 14	polymer	372	42720.7	1	UniProt (Q16539) Pfam (PF00069) In PDB	Homo sapiens (human)	Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
2	A	3-(2-chlorophenyl)-6-(2-fluorophenoxy)-2H-indazole	non-polymer		338.8	1	Chemie (FKO)
3		water	water		18.0	291	Chemie (HOH)

Sequence modifications

A: 1 - 360 (UniProt: Q16539)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Lys 57	Arg 57	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42720.7
Non-Polymers*	Number of molecules	1
	Total formula weight	338.8
All*	Total formula weight	43059.5

*Water molecules are not included.