3FJI

Crystal structure of K12V/C83I/C117V mutant of Human acidic fibroblast growth factor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Heparin-binding growth factor 1	polymer	146	16662.7	4	UniProt (P05230) Pfam (PF00167)	Homo sapiens (human)	HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta
2	E, F (A, D)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	G, H, I, J (A, B, C, D)	water	water		18.0	106	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Val 12	Lys 27	engineered mutation
Ile 83	Cys 98	engineered mutation
Val 117	Cys 132	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	66650.8
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	66842.9

*Water molecules are not included.