3FJD
Crystal structure of L44F/F132W mutant of Human acidic fibroblast growth factor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heparin-binding growth factor 1 | polymer | 146 | 16759.8 | 2 | UniProt (P05230) Pfam (PF00167) | Homo sapiens (human) | HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta |
| 2 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | D, E, F (A, B) | FORMIC ACID | non-polymer | 46.0 | 3 | Chemie (FMT) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 140 (UniProt: P05230)
| PDB | External Database | Details |
|---|---|---|
| His 1 | - | expression tag |
| His 1 | - | expression tag |
| His 1 | - | expression tag |
| His 1 | - | expression tag |
| His 1 | - | expression tag |
| His 1 | - | expression tag |
| Phe 44 | Leu 59 | engineered mutation |
| Trp 132 | Phe 147 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33519.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 234.1 | |
| All* | Total formula weight | 33753.7 |
