3FGA
Structural Basis of PP2A and Sgo interaction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 588 | 65261.2 | 1 | UniProt (Q76MZ3) Pfam (PF02985) Pfam (PF22646) Pfam (PF13646) | Mus musculus (mouse) | PP2A, subunit A, PR65-alpha isoform, PP2A, subunit A, R1-alpha isoform |
| 2 | B (B) | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | polymer | 403 | 47702.4 | 1 | UniProt (Q13362) Pfam (PF01603) | Homo sapiens (human) | PP2A, B subunit, B' gamma isoform, PP2A, B subunit, B56 gamma isoform, PP2A, B subunit, PR61 gamma isoform, PP2A, B subunit, R5 gamma isoform, Renal carcinoma antigen NY-REN-29 |
| 3 | C (C) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 309 | 35635.2 | 1 | UniProt (P67775) Pfam (PF00149) | Homo sapiens (human) | PP2A-alpha, Replication protein C, RP-C |
| 4 | D (D) | Shugoshin-like 1 | polymer | 47 | 5551.5 | 1 | UniProt (Q5FBB7) Pfam (PF07558) | Homo sapiens (human) | hSgo1, Serologically defined breast cancer antigen NY-BR-85 |
| 5 | E (E) | MICROCYSTIN-LR | polymer | 7 | 1014.2 | 1 | NOR (NOR00109) BIRD (PRD_000212) | Microcystis aeruginosa | |
| 6 | F, G (C) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 7 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
C: 1 - 309 (UniProt: P67775)
D: 51 - 96 (UniProt: Q5FBB7)
| PDB | External Database | Details |
|---|---|---|
| Asn 88 | Asp 88 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 50 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 155164.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 109.9 | |
| All* | Total formula weight | 155274.3 |
