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3F91

Structural Data for Human Active Site Mutant Enzyme Complexes

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ADihydrofolate reductasepolymer18721472.71UniProt (P00374)
Pfam (PF00186)
In PDB
Homo sapiens (human)
2A2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINEnon-polymer346.41Chemie (DH1)
3ANADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer745.41Chemie (NDP)
4ASULFATE IONnon-polymer96.12Chemie (SO4)
5waterwater18.0168Chemie (HOH)
Sequence modifications
A: 0 - 186 (UniProt: P00374)
PDBExternal DatabaseDetails
Ser 35Gln 36engineered mutation
Phe 64Asn 65engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight21472.7
Non-Polymers*Number of molecules4
Total formula weight1283.9
All*Total formula weight22756.7
*Water molecules are not included.

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PDB entries from 2024-07-24

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