3F8Z
Human Dihydrofolate Reductase Structural Data with Active Site Mutant Enzyme Complexes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 187 | 21412.6 | 1 | UniProt (P00374) Pfam (PF00186) | Homo sapiens (human) | |
| 2 | B (A) | 2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE | non-polymer | 346.4 | 1 | Chemie (DH1) | |||
| 3 | C (A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 4 | D, E, F, G, H (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | I (A) | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
A: 0 - 186 (UniProt: P00374)
| PDB | External Database | Details |
|---|---|---|
| Ser 35 | Gln 36 | engineered mutation |
| Ser 64 | Asn 65 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21412.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1572.1 | |
| All* | Total formula weight | 22984.8 |
