3F8S
Crystal structure of dipeptidyl peptidase IV in complex with inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dipeptidyl peptidase 4 | polymer | 748 | 86648.9 | 2 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) In PDB | Homo sapiens | Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Adenosine deaminase complexing protein 2, ADABP |
2 | C, D, E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
3 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
4 | A, B | 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine | non-polymer | 366.4 | 2 | Chemie (PF2) |
Sequence modifications
A, B: 31 - 766 (UniProt: P27487)
PDB | External Database | Details |
---|---|---|
Leu 767 | - | expression tag |
Val 768 | - | expression tag |
Pro 769 | - | expression tag |
Arg 770 | - | expression tag |
Gly 771 | - | expression tag |
Ser 772 | - | expression tag |
His 773 | - | expression tag |
His 774 | - | expression tag |
His 775 | - | expression tag |
His 776 | - | expression tag |
His 777 | - | expression tag |
His 778 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 173297.8 | |
Branched | Number of molecules | 4 |
Total formula weight | 1697.6 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1396.4 | |
All* | Total formula weight | 176391.9 |