3F3V

Kinase domain of cSrc in complex with inhibitor RL45 (Type II)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Proto-oncogene tyrosine-protein kinase Src	polymer	286	32742.7	2	UniProt (P00523) Pfam (PF07714)	Gallus gallus (Chicken)	pp60c-src, p60-Src, c-Src
2	C, D (A, B)	1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea	non-polymer		506.6	2	Chemie (1BU)
3	E, F (A, B)	water	water		18.0	53	Chemie (HOH)

Sequence modifications

A, B: 251 - 533 (UniProt: P00523)

PDB	External Database	Details
Gly 248	-	expression tag
His 249	-	expression tag
Met 250	-	expression tag
Cys 345	Ser 345	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65485.4
Non-Polymers*	Number of molecules	2
	Total formula weight	1013.2
All*	Total formula weight	66498.6

*Water molecules are not included.