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3F17

Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-(2-nitroso-2-oxoethyl)biphenyl-4-sulfonamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AMacrophage metalloelastasepolymer15817484.51UniProt (P39900)
Pfam (PF00413)
In PDB
Homo sapiensHME, Matrix metalloproteinase-12, MMP-12, Macrophage elastase, ME
2AZINC IONnon-polymer65.42Chemie (ZN)
3ACALCIUM IONnon-polymer40.13Chemie (CA)
4AN-oxidanyl-2-[(4-phenylphenyl)sulfonylamino]ethanamidenon-polymer306.31Chemie (HS4)
5waterwater18.0252Chemie (HOH)
Sequence modifications
A: 106 - 263 (UniProt: P39900)
PDBExternal DatabaseDetails
Asp 171Phe 171engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight17484.5
Non-Polymers*Number of molecules6
Total formula weight557.4
All*Total formula weight18041.9
*Water molecules are not included.

222036

PDB entries from 2024-07-03

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