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3F15

Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor (S)-N-(2,3-dihydroxypropyl)-4-methoxy-N-(2-nitroso-2-oxoethyl)benzenesulfonamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Macrophage metalloelastasepolymer15817484.51UniProt (P39900)
Pfam (PF00413)
Homo sapiens (human)HME, Matrix metalloproteinase-12, MMP-12, Macrophage elastase, ME
2B, C
(A)
ZINC IONnon-polymer65.42Chemie (ZN)
3D, E, F
(A)
CALCIUM IONnon-polymer40.13Chemie (CA)
4G
(A)
2-[[(2S)-2,3-dihydroxypropyl]-(4-methoxyphenyl)sulfonyl-amino]-N-oxo-ethanamidenon-polymer332.31Chemie (HS1)
5H
(A)
waterwater18.0139Chemie (HOH)
Sequence modifications
A: 106 - 263 (UniProt: P39900)
PDBExternal DatabaseDetails
Asp 171Phe 171engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight17484.5
Non-Polymers*Number of molecules6
Total formula weight583.4
All*Total formula weight18067.9
*Water molecules are not included.

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PDB entries from 2025-10-08

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