3F0X
Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Trimethoprim-sensitive dihydrofolate reductase | polymer | 157 | 18031.6 | 1 | UniProt (Q2YY41) | Staphylococcus aureus RF122 | |
| 2 | B (X) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | C (X) | 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | non-polymer | 386.5 | 1 | Chemie (53T) | |||
| 4 | D (X) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
X: 1 - 157 (UniProt: Q2YY41)
| PDB | External Database | Details |
|---|---|---|
| Tyr 98 | Phe 99 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18031.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1131.9 | |
| All* | Total formula weight | 19163.5 |
