3EX6
D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Orotidine-5'-phosphate decarboxylase | polymer | 260 | 28298.8 | 2 | UniProt (P11172) Pfam (PF00215) | Homo sapiens | OMPdecase |
| 2 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | D, F (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | G (B) | URIDINE-5'-MONOPHOSPHATE | non-polymer | 324.2 | 1 | Chemie (U5P) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 506 | Chemie (HOH) |
Sequence modifications
A, B: 224 - 480 (UniProt: P11172)
| PDB | External Database | Details |
|---|---|---|
| Gly 221 | - | expression tag |
| Ala 222 | - | expression tag |
| Met 223 | - | expression tag |
| Asn 312 | Asp 312 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56597.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 643.9 | |
| All* | Total formula weight | 57241.4 |
