3EWW

D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP, covalent adduct

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Orotidine-5'-phosphate decarboxylase	polymer	260	28298.8	2	UniProt (P11172) Pfam (PF00215)	Homo sapiens	OMPdecase
2	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
3	D, E (A, B)	6-[(E)-iminomethyl]uridine 5'-phosphate	non-polymer		351.2	2	Chemie (U1P)
4	F, G (A, B)	water	water		18.0	546	Chemie (HOH)

Sequence modifications

A, B: 224 - 480 (UniProt: P11172)

PDB	External Database	Details
Gly 221	-	expression tag
Ala 222	-	expression tag
Met 223	-	expression tag
Asn 312	Asp 312	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56597.5
Non-Polymers*	Number of molecules	3
	Total formula weight	794.5
All*	Total formula weight	57392.0

*Water molecules are not included.