3EWF
Crystal Structure Analysis of human HDAC8 H143A variant complexed with substrate.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone deacetylase 8 | polymer | 388 | 43107.9 | 4 | UniProt (Q9BY41) Pfam (PF00850) | Homo sapiens (Human) | HD8 |
| 2 | E, F, G, H (I, J, K, L) | PEPTIDIC SUBSTRATE | polymer | 5 | 679.8 | 4 | synthetic construct | ||
| 3 | I, L, M, P, S... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | J, K, N, O, Q... (A, B, C, D) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 5 | W, X, Y, Z (I, J, K, L) | 7-AMINO-4-METHYL-CHROMEN-2-ONE | non-polymer | 175.2 | 4 | Chemie (MCM) | |||
| 6 | AA, BA, CA, DA, EA... (A, B, C, D, I...) | water | water | 18.0 | 299 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 377 (UniProt: Q9BY41)
| PDB | External Database | Details |
|---|---|---|
| Ala 143 | His 143 | engineered mutation |
| Ile 378 | - | expression tag |
| Glu 379 | - | expression tag |
| Gly 380 | - | expression tag |
| Arg 381 | - | expression tag |
| Ser 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
| His 388 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 175150.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1406.0 | |
| All* | Total formula weight | 176556.7 |
