3ETQ
X-ray structure of cysteine-free fragment of mHCN2 C-terminal region from amino acids 443-630 including C508N, C584S, and C601S mutations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | polymer | 204 | 23871.2 | 2 | UniProt (O88703) Pfam (PF00027) | Mus musculus (mouse) | Brain cyclic nucleotide-gated channel 2, BCNG-2, Hyperpolarization-activated cation channel 1, HAC-1 |
| 2 | C, D (A, B) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 2 | Chemie (CMP) PubChem (176488666) PubChem (6076) PubChem (23902375) PubChem (25322948) PubChem (40467852) PubChem (44629928) PubChem (25322946) PubChem (56973690) PubChem (216878) PubChem (59909322) PubChem (59968988) PubChem (70878457) PubChem (59350541) PubChem (3080770) PubChem (3246347) PubChem (274) PubChem (6604194) PubChem (6603718) PubChem (6713792) PubChem (6714006) PubChem (124132380) PubChem (12071879) PubChem (12866365) PubChem (163043517) PubChem (129317551) PubChem (131841987) PubChem (134693155) PubChem (138107790) PubChem (163043518) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 541 | Chemie (HOH) |
Sequence modifications
A, B: 443 - 640 (UniProt: O88703)
| PDB | External Database | Details |
|---|---|---|
| Leu 437 | - | expression tag |
| Val 438 | - | expression tag |
| Pro 439 | - | expression tag |
| Arg 440 | - | expression tag |
| Gly 441 | - | expression tag |
| Ser 442 | - | expression tag |
| Asn 508 | Cys 508 | engineered mutation |
| Ser 584 | Cys 584 | engineered mutation |
| Ser 601 | Cys 601 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47742.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 658.4 | |
| All* | Total formula weight | 48400.9 |
