3ETQ
X-ray structure of cysteine-free fragment of mHCN2 C-terminal region from amino acids 443-630 including C508N, C584S, and C601S mutations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | polymer | 204 | 23871.2 | 2 | UniProt (O88703) Pfam (PF00027) | Mus musculus (mouse) | Brain cyclic nucleotide-gated channel 2, BCNG-2, Hyperpolarization-activated cation channel 1, HAC-1 |
| 2 | C, D (A, B) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 2 | Chemie (CMP) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 541 | Chemie (HOH) |
Sequence modifications
A, B: 443 - 640 (UniProt: O88703)
| PDB | External Database | Details |
|---|---|---|
| Leu 437 | - | expression tag |
| Val 438 | - | expression tag |
| Pro 439 | - | expression tag |
| Arg 440 | - | expression tag |
| Gly 441 | - | expression tag |
| Ser 442 | - | expression tag |
| Asn 508 | Cys 508 | engineered mutation |
| Ser 584 | Cys 584 | engineered mutation |
| Ser 601 | Cys 601 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47742.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 658.4 | |
| All* | Total formula weight | 48400.9 |
