3EQB
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 333 | 36859.5 | 1 | UniProt (Q02750) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK1 |
| 2 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | A | N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine | non-polymer | 475.2 | 1 | Chemie (LUG) | |||
| 5 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 62 - 393 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Met 61 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36859.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1006.7 | |
| All* | Total formula weight | 37866.2 |
