3EKN
Insulin receptor kinase complexed with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin receptor | polymer | 307 | 34849.8 | 1 | UniProt (P06213) Pfam (PF07714) | Homo sapiens (human) | IR, Insulin receptor subunit alpha, Insulin receptor subunit beta |
| 2 | B (A) | 2-fluoro-6-{[2-({2-methoxy-4-[4-(1-methylethyl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide | non-polymer | 518.6 | 1 | Chemie (GS3) | |||
| 3 | C (A) | water | water | 18.0 | 221 | Chemie (HOH) |
Sequence modifications
A: 978 - 1283 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| Gly 977 | - | expression tag |
| Ser 981 | Cys 1008 | engineered mutation |
| Asn 1132 | Asp 1159 | engineered mutation |
| Asn 1251 | Lys 1278 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34849.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 518.6 | |
| All* | Total formula weight | 35368.4 |
