3EJS
Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5S)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Alpha-mannosidase 2 | polymer | 1045 | 119701.6 | 1 | UniProt (Q24451) Pfam (PF01074) Pfam (PF09261) Pfam (PF21260) Pfam (PF07748) Pfam (PF18230) | Drosophila melanogaster (Fruit fly) | Alpha-mannosidase II, AMAN II, MAN II, Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, Golgi alpha-mannosidase II |
| 2 | B (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 1 | Chemie (MRD) | |||
| 5 | E (A) | (1S,2R,5S,8R,8aR)-5-[2-(4-tert-butylphenyl)ethyl]octahydroindolizine-1,2,8-triol | non-polymer | 333.5 | 1 | Chemie (HN5) | |||
| 6 | F (A) | water | water | 18.0 | 1178 | Chemie (HOH) |
Sequence modifications
A: 13 - 1045 (UniProt: Q24451)
| PDB | External Database | Details |
|---|---|---|
| Arg 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Ser 3 | - | expression tag |
| His 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| Gly 10 | - | expression tag |
| Glu 11 | - | expression tag |
| Phe 12 | - | expression tag |
| Lys 907 | Glu 970 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 119701.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 738.3 | |
| All* | Total formula weight | 120439.9 |
