3EGH
Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1), the PP1 binding and PDZ domains of Spinophilin and the small natural molecular toxin Nodularin-R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | polymer | 329 | 37349.8 | 2 | UniProt (P62136) Pfam (PF16891) Pfam (PF00149) | Homo sapiens (Human) | PP-1A |
| 2 | C, D (C, D) | Spinophilin | polymer | 170 | 18571.6 | 2 | UniProt (O35274) Pfam (PF17817) Pfam (PF00595) | Rattus norvegicus (Rat) | Neurabin-II, Neurabin-2, Protein phosphatase 1 regulatory subunit 9B, Neural tissue-specific F-actin-binding protein II, p130, PP1bp134 |
| 3 | E, F (E, F) | nodularin R | polymer | 5 | 844.0 | 2 | NOR (NOR00279) BIRD (PRD_000214) | Nodularia spumigena | |
| 4 | G, H, I, N (A, C) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | J, K, L, M (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 6 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 481 | Chemie (HOH) |
Sequence modifications
A, B: 7 - 330 (UniProt: P62136)
C, D: 417 - 583 (UniProt: O35274)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | - | expression tag |
| His 3 | - | expression tag |
| Met 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Ser 6 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 414 | - | expression tag |
| Ser 415 | - | expression tag |
| Met 416 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 113530.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 588.1 | |
| All* | Total formula weight | 114118.9 |
