3EEJ

Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-phenylphenyl)prop-1-ynyl]-6-methylpyrimidine(UCP111D) and NADPH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Dihydrofolate reductase	polymer	227	26427.3	2	UniProt (Q6FPH0) Pfam (PF00186) In PDB	Candida glabrata (yeast)
2	A, B	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
3	A, B	5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine	non-polymer		358.4	2	Chemie (53R)
4		water	water		18.0	190	Chemie (HOH)

Sequence modifications

A, B: 1 - 217 (UniProt: Q6FPH0)

PDB	External Database	Details
Leu 218	-	expression tag
Glu 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52854.7
Non-Polymers*	Number of molecules	4
	Total formula weight	2207.7
All*	Total formula weight	55062.4

*Water molecules are not included.