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3E8D

Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BRAC-beta serine/threonine-protein kinasepolymer33539072.52UniProt (P31751)
Pfam (PF00069)
Pfam (PF00433)
In PDB
Homo sapiens (human)RAC-PK-beta, Protein kinase Akt-2, Protein kinase B, beta, PKB beta
2C, DGlycogen synthase kinase-3 beta peptidepolymer101123.22UniProt (P49841)
In PDB
GSK-3 beta
3A, B4-[2-(4-amino-2,5-dihydro-1,2,5-oxadiazol-3-yl)-6-{[(1S)-3-amino-1-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-olnon-polymer463.52Chemie (G98)
4waterwater18.041Chemie (HOH)
Sequence modifications
A, B: 146 - 480 (UniProt: P31751)
PDBExternal DatabaseDetails
Asp 474Ser 474engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight80391.5
Non-Polymers*Number of molecules2
Total formula weight927.1
All*Total formula weight81318.5
*Water molecules are not included.

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PDB entries from 2024-03-27

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