3E8D
Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RAC-beta serine/threonine-protein kinase | polymer | 335 | 39072.5 | 2 | UniProt (P31751) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | RAC-PK-beta, Protein kinase Akt-2, Protein kinase B, beta, PKB beta |
| 2 | C, D (C, D) | Glycogen synthase kinase-3 beta peptide | polymer | 10 | 1123.2 | 2 | UniProt (P49841) | GSK-3 beta | |
| 3 | E, F (A, B) | 4-[2-(4-amino-2,5-dihydro-1,2,5-oxadiazol-3-yl)-6-{[(1S)-3-amino-1-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol | non-polymer | 463.5 | 2 | Chemie (G98) | |||
| 4 | G, H, I (A, B, D) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, B: 146 - 480 (UniProt: P31751)
| PDB | External Database | Details |
|---|---|---|
| Asp 474 | Ser 474 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 80391.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 927.1 | |
| All* | Total formula weight | 81318.5 |
