3E64
Fragment based discovery of JAK-2 inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK2 | polymer | 293 | 34678.5 | 1 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 2, JAK-2 |
| 2 | B (A) | 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide | non-polymer | 344.4 | 1 | Chemie (5B3) | |||
| 3 | C (A) | water | water | 18.0 | 338 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34678.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 344.4 | |
| All* | Total formula weight | 35022.9 |
