3E2M
LFA-1 I domain bound to inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Integrin alpha-L | polymer | 185 | 21094.2 | 2 | UniProt (P20701) Pfam (PF00092) In PDB | Homo sapiens (Human) | Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a antigen |
| 2 | A, B | cis-4-{[2-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)phenoxy]methyl}cyclohexanecarboxylic acid | non-polymer | 617.6 | 2 | Chemie (E2M) | |||
| 3 | water | water | 18.0 | 368 | Chemie (HOH) |
Sequence modifications
A, B: 127 - 309 (UniProt: P20701)
| PDB | External Database | Details |
|---|---|---|
| Gly 125 | - | expression tag |
| Ser 126 | - | expression tag |
| Trp 189 | Arg 214 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42188.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1235.2 | |
| All* | Total formula weight | 43423.5 |
