3E04

Crystal structure of human fumarate hydratase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Fumarate hydratase	polymer	490	52960.5	4	UniProt (P07954) Pfam (PF00206) Pfam (PF10415) In PDB	Homo sapiens (human)	Fumarase
2	A, B	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
3		water	water		18.0	655	Chemie (HOH)

Sequence modifications

A, B, C, D: 44 - 510 (UniProt: P07954)

PDB	External Database	Details
Met 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
His 27	-	expression tag
Ser 28	-	expression tag
Ser 29	-	expression tag
Gly 30	-	expression tag
Val 31	-	expression tag
Asp 32	-	expression tag
Leu 33	-	expression tag
Gly 34	-	expression tag
Thr 35	-	expression tag
Glu 36	-	expression tag
Asn 37	-	expression tag
Leu 38	-	expression tag
Tyr 39	-	expression tag
Phe 40	-	expression tag
Gln 41	-	expression tag
Ser 42	-	expression tag
Met 43	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	211842.0
Non-Polymers*	Number of molecules	3
	Total formula weight	186.2
All*	Total formula weight	212028.2

*Water molecules are not included.