3DZY
Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with Rosiglitazone, 9-cis Retinoic Acid and NCOA2 Peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 467 | 51527.9 | 1 | UniProt (P19793) Pfam (PF11825) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (Human) | Retinoid X receptor alpha, Nuclear receptor subfamily 2 group B member 1 |
| 2 | B (D) | Peroxisome proliferator-activated receptor gamma | polymer | 419 | 48163.6 | 1 | UniProt (P37231) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (Human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 3 | C (C) | DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3') | polymer | 20 | 6176.0 | 1 | |||
| 4 | D (F) | DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DCP*DTP*DTP*DTP*DGP*DAP*DCP*DCP*DTP*DAP*DGP*DTP*DTP*DTP*DG)-3') | polymer | 20 | 6090.9 | 1 | |||
| 5 | E, F (G, E) | NCOA2 Peptide | polymer | 13 | 1621.9 | 2 | UniProt (Q15596) | ||
| 6 | G (A) | (9cis)-retinoic acid | non-polymer | 300.4 | 1 | Chemie (9CR) | |||
| 7 | H, I, K, L (A, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 8 | J (D) | 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) | non-polymer | 357.4 | 1 | Chemie (BRL) |
Sequence modifications
A: 11 - 462 (UniProt: P19793)
D: 74 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | expression tag |
| Ala -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| His 2 | - | expression tag |
| His 3 | - | expression tag |
| Val 4 | - | expression tag |
| Asp 5 | - | expression tag |
| Asp 6 | - | expression tag |
| Asp 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Lys 9 | - | expression tag |
| Met 10 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 59 | - | expression tag |
| Ala 60 | - | expression tag |
| His 61 | - | expression tag |
| His 62 | - | expression tag |
| His 63 | - | expression tag |
| His 64 | - | expression tag |
| His 65 | - | expression tag |
| His 66 | - | expression tag |
| Val 67 | - | expression tag |
| Asp 68 | - | expression tag |
| Asp 69 | - | expression tag |
| Asp 70 | - | expression tag |
| Asp 71 | - | expression tag |
| Lys 72 | - | expression tag |
| Met 73 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 115202.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 919.5 | |
| All* | Total formula weight | 116121.8 |
