3DRS
HIV reverse transcriptase K103N mutant in complex with inhibitor R8D
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/ribonuclease H | polymer | 563 | 64880.2 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 (HIV-1) | Rp66 RT |
| 2 | B (B) | p66 RT | polymer | 443 | 51716.3 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 (HIV-1) | |
| 3 | C (A) | 3-chloro-5-[2-chloro-5-(1H-pyrazolo[3,4-b]pyridin-3-ylmethoxy)phenoxy]benzonitrile | non-polymer | 411.2 | 1 | Chemie (R8D) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 103 | Lys 690 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 103 | Lys 690 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 116596.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 411.2 | |
| All* | Total formula weight | 117007.8 |
