3DRS

HIV reverse transcriptase K103N mutant in complex with inhibitor R8D

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Reverse transcriptase/ribonuclease H	polymer	563	64880.2	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus type 1 (HIV-1)	Rp66 RT
2	B	p66 RT	polymer	443	51716.3	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus type 1 (HIV-1)
3	A	3-chloro-5-[2-chloro-5-(1H-pyrazolo[3,4-b]pyridin-3-ylmethoxy)phenoxy]benzonitrile	non-polymer		411.2	1	Chemie (R8D)

Sequence modifications

A: 1 - 560 (UniProt: P04585)

PDB	External Database	Details
Met -2	-	expression tag
Asn -1	-	expression tag
Ser 0	-	expression tag
Asn 103	Lys 690	engineered mutation

B: 1 - 440 (UniProt: P04585)

PDB	External Database	Details
Met -2	-	expression tag
Asn -1	-	expression tag
Ser 0	-	expression tag
Asn 103	Lys 690	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	116596.6
Non-Polymers*	Number of molecules	1
	Total formula weight	411.2
All*	Total formula weight	117007.8

*Water molecules are not included.