3DRR
HIV reverse transcriptase Y181C mutant in complex with inhibitor R8e
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/ribonuclease H | polymer | 563 | 64835.3 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 (HIV-1) | p66 RT |
| 2 | B (B) | p51 RT | polymer | 443 | 51671.4 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 (HIV-1) | |
| 3 | C (A) | 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile | non-polymer | 426.3 | 1 | Chemie (R8E) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Cys 181 | Tyr 768 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Cys 181 | Tyr 768 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 116506.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 426.3 | |
| All* | Total formula weight | 116932.9 |
