3DOG
Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Cell division protein kinase 2 | polymer | 299 | 34143.5 | 2 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | p33 protein kinase, CDK2 |
| 2 | B, D (B, D) | Cyclin-A2 | polymer | 264 | 30285.9 | 2 | UniProt (P30274) Pfam (PF00134) Pfam (PF02984) | Bos taurus (bovine cow) | Cyclin-A |
| 3 | E, H (A, C) | (2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol | non-polymer | 354.4 | 2 | Chemie (NNN) | |||
| 4 | F, G, I (B, D) | MONOTHIOGLYCEROL | non-polymer | 108.2 | 3 | Chemie (SGM) | |||
| 5 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
B, D: 171 - 432 (UniProt: P30274)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 433 | - | expression tag |
| His 434 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128858.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1033.4 | |
| All* | Total formula weight | 129892.2 |
