3DGC

Structure of IL-22/IL-22R1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L, M	Interleukin-22	polymer	141	16343.9	2	UniProt (Q9GZX6) Pfam (PF14565) In PDB	Homo sapiens (human)	IL-22, IL-10-related T-cell-derived-inducible factor, IL-TIF
2	R, S	Interleukin-22 receptor subunit alpha-1	polymer	210	23957.1	2	UniProt (Q9HB22) Pfam (PF01108) UniProt (by SIFTS) (Q8N6P7) In PDB	Homo sapiens (human)	IL-22R-alpha-1, Cytokine receptor family 2 member 9, CRF2-9
3	A	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		894.8	1	In PDB GlyTouCan (G00395TQ)
4	L, R, M, S	URANIUM ATOM	non-polymer		238.0	11	Chemie (U1)
5	R, S	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
6	M	URANYL (VI) ION	non-polymer		270.0	1	Chemie (IUM)
7	M	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
8		water	water		18.0	164	Chemie (HOH)

Sequence modifications

L, M: 39 - 179 (UniProt: Q9GZX6)

PDB	External Database	Details
Gln 68	Asn 68	expression tag
Gln 97	Asn 97	expression tag

R, S: 17 - 226 (UniProt: Q9HB22)

PDB	External Database	Details
Asp 80	Asn 80	expression tag
Asp 87	Asn 87	expression tag
Gln 89	Thr 89	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	80602.0
Branched	Number of molecules	1
	Total formula weight	894.8
Non-Polymers*	Number of molecules	17
	Total formula weight	3112.8
All*	Total formula weight	84609.6

*Water molecules are not included.