3DG8
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 280 | 33213.3 | 2 | UniProt (Q8I1R6) Pfam (PF00186) UniProt (by SIFTS) (P13922) In PDB | Plasmodium falciparum | |
2 | C, D | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 328 | 38712.9 | 2 | UniProt (Q8I1R6) Pfam (PF00303) UniProt (by SIFTS) (P13922) In PDB | Plasmodium falciparum | |
3 | A, B | N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide | non-polymer | 237.3 | 2 | Chemie (RJ6) | |||
4 | A, B | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
5 | C, D | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) | |||
6 | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 280 (UniProt: Q8I1R6)
PDB | External Database | Details |
---|---|---|
Ile 51 | Asn 51 | engineered mutation |
Arg 59 | Cys 59 | engineered mutation |
Asn 108 | Ser 108 | engineered mutation |
Leu 164 | Ile 164 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 143852.5 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2581.7 | |
All* | Total formula weight | 146434.2 |