3DFR
CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
Replaces: 1DFREntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DIHYDROFOLATE REDUCTASE | polymer | 162 | 18345.7 | 1 | UniProt (P00381) Pfam (PF00186) In PDB | Lactobacillus casei | |
| 2 | A | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | A | METHOTREXATE | non-polymer | 454.4 | 1 | Chemie (MTX) | |||
| 4 | water | water | 18.0 | 264 | Chemie (HOH) |
Sequence modifications
A: 1 - 162 (UniProt: P00381)
| PDB | External Database | Details |
|---|---|---|
| Asn 8 | Asp 8 | conflict |
| Asn 10 | Asp 10 | conflict |
| Leu 90 | Pro 90 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18345.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1199.9 | |
| All* | Total formula weight | 19545.5 |
