3DDU
Prolyl Oligopeptidase with GSK552
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prolyl endopeptidase | polymer | 709 | 80678.1 | 1 | UniProt (P48147) Pfam (PF02897) Pfam (PF00326) | Homo sapiens (human) | Prolyl Oligopeptidase; Post-proline cleaving enzyme; PE |
| 2 | B, C, D, E, F (A) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 3 | G (A) | (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one | non-polymer | 389.8 | 1 | Chemie (552) | |||
| 4 | H (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | I (A) | water | water | 18.0 | 1234 | Chemie (HOH) |
Sequence modifications
A: 2 - 710 (UniProt: P48147)
| PDB | External Database | Details |
|---|---|---|
| His 307 | Gln 307 | engineered mutation |
| Thr 319 | Trp 319 | engineered mutation |
| Thr 360 | Ile 360 | engineered mutation |
| Ile 374 | Thr 374 | engineered mutation |
| Asn 667 | Ser 667 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 80678.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 777.1 | |
| All* | Total formula weight | 81455.2 |
