3DBE
Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 557
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polo-like kinase 1 | polymer | 301 | 34442.1 | 1 | UniProt (Q4KMI8) Pfam (PF00069) | Danio rerio (Zebrafish) | |
| 2 | B (A) | 3'-chloro-5'-[6-({2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)-3-methyl-1H-pyrazolo[4,3-c]pyridin-1-yl]biphenyl-2-carboxamide | non-polymer | 624.1 | 1 | Chemie (4FR) |
Sequence modifications
A: 17 - 312 (UniProt: Q4KMI8)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| Pro 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Asp 196 | Thr 196 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34442.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 624.1 | |
| All* | Total formula weight | 35066.2 |
