3DBD
Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 094
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polo-like kinase 1 | polymer | 317 | 35993.0 | 1 | UniProt (Q4KMI8) Pfam (PF00069) | Danio rerio (Zebrafish) | |
| 2 | B (A) | 3'-chloro-5'-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)biphenyl-2-carboxamide | non-polymer | 482.0 | 1 | Chemie (3FR) | |||
| 3 | C (A) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 1 - 312 (UniProt: Q4KMI8)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asp 196 | Thr 196 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35993.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 482.0 | |
| All* | Total formula weight | 36474.9 |
