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3D9V

CRYSTAL STRUCTURE OF ROCK I BOUND TO H-1152P A DI-METHYLATED VARIANT OF FASUDIL

Replaces:  2ETO
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Rho-associated protein kinase 1polymer41548012.32UniProt (Q13464)
Pfam (PF00069)
Homo sapiens (Human)Rho-associated, coiled-coil-containing protein kinase 1, p160 ROCK-1, p160ROCK, Renal carcinoma antigen NY-REN-35
2C, D
(A, B)
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINEnon-polymer319.42Chemie (H52)
Sequence modifications
A, B: 6 - 415 (UniProt: Q13464)
PDBExternal DatabaseDetails
Gly 1-expression tag
Ser 2-expression tag
Leu 3-expression tag
His 4-expression tag
Met 5-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight96024.6
Non-Polymers*Number of molecules2
Total formula weight638.8
All*Total formula weight96663.4
*Water molecules are not included.

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PDB entries from 2025-06-11

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