3D7T

Structural basis for the recognition of c-Src by its inactivator Csk

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein kinase CSK	polymer	269	29976.6	1	UniProt (P41240) Pfam (PF07714)	Homo sapiens (human)	C-SRC kinase, Protein-tyrosine kinase CYL
2	B (B)	Proto-oncogene tyrosine-protein kinase Src	polymer	286	32726.6	1	UniProt (P00523) Pfam (PF07714)	Gallus gallus (chicken)	pp60c-src, p60-Src, c-Src
3	C, D (A, B)	STAUROSPORINE	non-polymer		466.5	2	Chemie (STU)

Sequence modifications

A: 188 - 450 (UniProt: P41240)

PDB	External Database	Details
Gly 182	-	expression tag
Pro 183	-	expression tag
Leu 184	-	expression tag
Gly 185	-	expression tag
Ser 186	-	expression tag
Gly 187	-	expression tag
Ala 361	Lys 361	engineered mutation
Ala 362	Lys 362	engineered mutation

B: 258 - 533 (UniProt: P00523)

PDB	External Database	Details
Gly 248	-	expression tag
His 249	-	expression tag
Met 250	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62703.2
Non-Polymers*	Number of molecules	2
	Total formula weight	933.1
All*	Total formula weight	63636.3

*Water molecules are not included.