3D7T
Structural basis for the recognition of c-Src by its inactivator Csk
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase CSK | polymer | 269 | 29976.6 | 1 | UniProt (P41240) Pfam (PF07714) In PDB | Homo sapiens (human) | C-SRC kinase, Protein-tyrosine kinase CYL |
2 | B | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32726.6 | 1 | UniProt (P00523) Pfam (PF07714) In PDB | Gallus gallus (chicken) | pp60c-src, p60-Src, c-Src |
3 | A, B | STAUROSPORINE | non-polymer | 466.5 | 2 | Chemie (STU) |
Sequence modifications
A: 188 - 450 (UniProt: P41240)
B: 258 - 533 (UniProt: P00523)
PDB | External Database | Details |
---|---|---|
Gly 182 | - | expression tag |
Pro 183 | - | expression tag |
Leu 184 | - | expression tag |
Gly 185 | - | expression tag |
Ser 186 | - | expression tag |
Gly 187 | - | expression tag |
Ala 361 | Lys 361 | engineered mutation |
Ala 362 | Lys 362 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 248 | - | expression tag |
His 249 | - | expression tag |
Met 250 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 62703.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 933.1 | |
All* | Total formula weight | 63636.3 |