3D57

TR Variant D355R

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Thyroid hormone receptor beta	polymer	266	30127.8	2	UniProt (P10828) Pfam (PF00104) In PDB	Homo sapiens (human)	Nuclear receptor subfamily 1 group A member 2
2	A, B	[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID	non-polymer		621.9	2	Chemie (4HY)
3	B	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4		water	water		18.0	105	Chemie (HOH)

Sequence modifications

A, B: 209 - 460 (UniProt: P10828)

PDB	External Database	Details
Met 195	-	expression tag
Gly 196	-	expression tag
Ser 197	-	expression tag
Ser 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
Ser 205	-	expression tag
Gln 206	-	expression tag
Asp 207	-	expression tag
Pro 208	-	expression tag
Arg 355	Asp 355	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	60255.6
Non-Polymers*	Number of molecules	3
	Total formula weight	1339.9
All*	Total formula weight	61595.5

*Water molecules are not included.