3D4S

Cholesterol bound form of human beta2 adrenergic receptor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Beta-2 adrenergic receptor/T4-lysozyme chimera	polymer	490	55957.9	1	UniProt (P07550) UniProt (P00720) Pfam (PF00001) Pfam (PF00959)	Homo sapiens	Beta-2 adrenoceptor, Beta-2 adrenoreceptor / Lysis protein, Muramidase, Endolysin
2	B (A)	(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol	non-polymer		316.4	1	Chemie (TIM)
3	C, D (A)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)
4	E, F, G (A)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	3	Chemie (OLC)
5	H (A)	water	water		18.0	20	Chemie (HOH)

Sequence modifications

A: 1 - 230 (UniProt: P07550)

PDB	External Database	Details
Asp -7	-	expression tag
Tyr -6	-	expression tag
Lys -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Ala 0	-	expression tag
Trp 122	Glu 122	engineered mutation
Glu 187	Asn 187	engineered mutation
His 349	-	expression tag
His 350	-	expression tag
His 351	-	expression tag
His 352	-	expression tag
His 353	-	expression tag
His 354	-	expression tag

A: 1002 - 1161 (UniProt: P00720)

PDB	External Database	Details
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation

A: 263 - 348 (UniProt: P07550)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	55957.9
Non-Polymers*	Number of molecules	6
	Total formula weight	2159.3
All*	Total formula weight	58117.3

*Water molecules are not included.