3D2U
Structure of UL18, a Peptide-Binding Viral MHC Mimic, Bound to a Host Inhibitory Receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, E) | UL18 protein | polymer | 281 | 31665.0 | 2 | UniProt (Q4A1U8) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P08560) | Human herpesvirus 5 (Human cytomegalovirus) | |
| 2 | B, E (B, F) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 2 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C, F (D, H) | Leukocyte immunoglobulin-like receptor subfamily B member 1 | polymer | 198 | 22055.7 | 2 | UniProt (Q8NHL6) Pfam (PF13895) | Homo sapiens (human) | Leukocyte immunoglobulin-like receptor 1, LIR-1, Immunoglobulin- like transcript 2, ILT-2, Monocyte/macrophage immunoglobulin-like receptor 7, MIR-7, CD85j antigen |
| 4 | G, H (G, C) | Actin | polymer | 9 | 1005.3 | 2 | UniProt (P60709) | Homo sapiens | |
| 5 | I, J, N, O, P... (A, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 13 | Chemie (NAG) | |||
| 6 | K (A) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) | |||
| 7 | L (A) | beta-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (BMA) | |||
| 8 | M (A) | alpha-L-fucopyranose | non-polymer | 164.2 | 1 | Chemie (FUC) | |||
| 9 | AA, BA, CA, DA, Y... (D, E, F, H, A...) | water | water | 18.0 | 362 | Chemie (HOH) |
Sequence modifications
A, E: 1 - 281 (UniProt: Q4A1U8)
D, H: 1 - 198 (UniProt: Q8NHL6)
| PDB | External Database | Details |
|---|---|---|
| Gln 36 | Asn 56 | engineered mutation |
| Gln 147 | Asn 167 | engineered mutation |
| Pro 186 | Thr 206 | variant |
| Gln 220 | Asn 240 | engineered mutation |
| Ser 259 | Cys 279 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 45 | Leu 68 | variant |
| Thr 119 | Ile 142 | variant |
| Ile 132 | Ser 155 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 132948.2 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3400.2 | |
| All* | Total formula weight | 136348.4 |
