3D2I
Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylamino)-ethyl]-thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | serine/threonine kinase 6 | polymer | 272 | 31549.2 | 1 | UniProt (Q8C3H8) Pfam (PF00069) UniProt (by SIFTS) (P97477) In PDB | Mus musculus (mouse) | |
| 2 | A | 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea | non-polymer | 462.5 | 1 | Chemie (AK3) | |||
| 3 | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 138 - 404 (UniProt: Q8C3H8)
| PDB | External Database | Details |
|---|---|---|
| Gly 133 | - | expression tag |
| Pro 134 | - | expression tag |
| Leu 135 | - | expression tag |
| Gly 136 | - | expression tag |
| Ser 137 | - | expression tag |
| Gly 186 | Asn 164 | engineered mutation |
| Arg 240 | Lys 218 | engineered mutation |
| Leu 302 | Met 280 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31549.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 462.5 | |
| All* | Total formula weight | 32011.6 |
