3D09
Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cellular tumor antigen p53 | polymer | 200 | 22424.5 | 1 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (Human) | Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Ala 123 | Thr 123 | engineered mutation |
| Arg 168 | His 168 | engineered mutation |
| Ser 249 | Arg 249 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22424.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 22489.9 |
